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PKIs and Digital Signatures

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I am trying to implement an Digital Signature solution that meets the requirement in the below regulation.

 

CFR - Code of Federal Regulations Title 21

 

In Adobe Reader when you digitally sign a document, there is an option to create a self signed certificate for signing. Will this hold up with this regulation? I have seen third party document signing USB PKI certs that also allow for signing. I'm just not sure why I would go with a third party cert over a self signed cert.

 

Thanks for your help.


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